### Jaguars vs. Colts: A Crucial Week 17 Showdown in the AFC South The Jacksonville Jaguars (11-4) are set to face off against the Indianapolis Colts (8-7) in a pivotal Week 17 matchup of the 2025 NFL season. This game is significant for both teams, as the Jaguars are looking to solidify their playoff position and potentially clinch the AFC South title, while the Colts are fighting to keep their slim playoff hopes alive. The game will take place at Lucas Oil Stadium in Indianapolis, with kickoff scheduled for 1:00 PM ET on December 28, 2025 [https://sports.yahoo.com/articles/week-17-jacksonville-jaguars-indianapolis-174204123.html]. ### Breakdown of the Matchup and Stakes 1. **Team Performance and Standings** - The Jaguars are currently leading the AFC South with an 11-4 record, having recently secured a playoff berth. - The Colts, at 8-7, are in a must-win situation to maintain any chance of making the playoffs [https://www.jacksonville.com/story/sports/nfl/jaguars/2025/12/28/jaguars-colts-predictions-picks-odds-week-17/87899919007]. 2. **Key Players to Watch** - **Trevor Lawrence**: The Jaguars' quarterback is expected to play a crucial role, with predictions suggesting he could throw for over 300 yards [https://sports.yahoo.com/articles/jaguars-vs-colts-bold-predictions-155040348.html]. - **Jonathan Taylor**: The Colts' running back will be pivotal for their offensive strategy, especially given the stakes of the game [https://foxsports1260.iheart.com/content/2025-12-26-jonathan-taylor-week-17-preview-vs-the-jaguars]. 3. **Game Predictions and Odds** - Analysts are favoring the Jaguars due to their strong offensive performance throughout the season, with many expecting them to dominate the Colts [https://covers.com/nfl/jaguars-vs-colts-predictions-picks-best-bets-today-december-28-2025]. - Betting lines indicate a significant edge for Jacksonville, reflecting their current form and the Colts' struggles [https://www.si.com/betting/jaguars-vs-colts-prediction-odds-spread-injuries-trends-for-nfl-week-17-01kd5spxac48]. ### Supporting Evidence and Data - **Recent Performance**: The Jaguars recently defeated the Colts 36-19 in their last meeting, showcasing their offensive capabilities [https://winnersandwhiners.com/free-picks/nfl/jacksonville-jaguars-vs-indianapolis-colts-picks-and-predictions-sunday-december-28th-2025]. - **Playoff Implications**: A win for the Jaguars could clinch the division title, while a loss for the Colts would likely eliminate them from playoff contention [https://bluewaterhealthyliving.com/news/national-news/florida/3-things-to-watch-in-week-17-jaguars-vs-colts-plus-a-prediction]. ### Conclusion: A Defining Moment for Both Teams In summary, the Week 17 clash between the Jacksonville Jaguars and Indianapolis Colts is not just another game; it is a defining moment for both teams. 1. **Jaguars' Opportunity**: With a chance to clinch the AFC South title, the Jaguars are in a strong position, bolstered by their recent performances and key players like Trevor Lawrence. 2. **Colts' Last Stand**: The Colts face a do-or-die scenario, needing a win to keep their playoff hopes alive, making this matchup critical for their season. 3. **Predictions Favor Jaguars**: Analysts largely predict a Jaguars victory, citing their offensive strength and recent form as key factors. The outcome of this game will have significant implications for the playoff landscape in the AFC, making it a must-watch for fans and analysts alike [https://www.si.com/nfl/colts/onsi/news/colts-3-bold-jaguars-predictions-playoff-hopes-at-stake].