### Kyler Murray's Injury: Impact on Cardinals' Week 6 Matchup Against Colts The Arizona Cardinals are facing a significant challenge as their starting quarterback, Kyler Murray, is expected to miss the upcoming Week 6 game against the Indianapolis Colts due to a foot injury. Murray sustained this injury during the Cardinals' unexpected loss to the Tennessee Titans in Week 5, where he was temporarily sidelined before returning to finish the game. The Cardinals are now preparing for backup quarterback Jacoby Brissett to take the lead in this crucial matchup, as they aim to improve their 2-3 record against a strong Colts team that currently stands at 4-1. *While there remains a slim chance for Murray to play, preparations for Brissett have already begun, indicating a likely absence for Murray that could extend beyond just this week* [https://www.cbssports.com/nfl/news/cardinals-qb-kyler-murray-expected-to-miss-week-6-game-vs-colts-with-foot-injury-jacoby-brissett-to-start]. ### Breakdown of Kyler Murray's Situation and Team Preparations 1. **Injury Details**: - Kyler Murray is dealing with a mid-foot sprain, which is a type of Lisfranc injury. This injury occurred during a botched snap in the third quarter of the game against the Titans [https://www.yardbarker.com/nfl/articles/cardinals_qb_kyler_murray_out_week_6_vs_colts_qb_jacoby_brissett_to_start/s1_17087_42885920]. - He was unable to practice for most of the week, raising concerns about his availability for the Colts game [https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/kyler-murray-wont-practice-wednesday-with-foot-injury]. 2. **Backup Plans**: - Jacoby Brissett is set to start in Murray's place. This will be Brissett's first start for the Cardinals, and he has previously played for the Colts, adding an interesting narrative to the matchup [https://www.si.com/nfl/cardinals-qb-kyler-murray-will-miss-sunday-s-game-vs-colts]. - The Cardinals have been preparing for Brissett to take over, indicating that they expect Murray's absence to last at least a week, if not longer [https://www.yardbarker.com/nfl/articles/cardinals_make_decision_on_kyler_murray_for_week_6/s1_127_42885913]. 3. **Team Performance Context**: - The Cardinals currently hold a 2-3 record, while the Colts are performing well at 4-1, making this game critical for Arizona's season [https://www.yardbarker.com/nfl/articles/cardinals_qb_kyler_murray_out_week_6_vs_colts_qb_jacoby_brissett_to_start/s1_17087_42885920]. - Murray has been a key player for the Cardinals, throwing for 962 yards with 6 touchdowns and 3 interceptions in the first five weeks of the season [https://www.yardbarker.com/nfl/articles/cardinals_make_decision_on_kyler_murray_for_week_6/s1_127_42885913]. ### Summary of Findings and Implications for the Cardinals **Key Conclusions**: 1. **Kyler Murray's Absence**: Murray is expected to miss the Week 6 game against the Colts due to a mid-foot sprain, which could lead to a multi-week absence [https://www.cbssports.com/nfl/news/cardinals-qb-kyler-murray-expected-to-miss-week-6-game-vs-colts-with-foot-injury-jacoby-brissett-to-start]. 2. **Jacoby Brissett's Role**: Brissett will start in Murray's place, marking a significant shift in the team's offensive strategy [https://www.si.com/nfl/cardinals-qb-kyler-murray-will-miss-sunday-s-game-vs-colts]. 3. **Impact on Team Dynamics**: The Cardinals must adapt quickly to maintain competitiveness against a strong Colts team, making this a pivotal moment in their season [https://www.yardbarker.com/nfl/articles/cardinals_make_decision_on_kyler_murray_for_week_6/s1_127_42885913]. In conclusion, the Cardinals are bracing for a challenging game against the Colts without their star quarterback, which could have lasting implications for their season trajectory.